An ansa macrolide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Maytansinol

Item No. 29228

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-O-de[2-(acetylmethylamino)-1-oxopropyl]-maytansine
CAS Number
57103-68-1
Synonyms
  • Ansamitocin P-0
  • Antibiotic C-15003P0
  • NSC 239386
Molecular Formula
C28H37ClN2O8
Formula Weight
565.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): Partially soluble
λmax
232, 244, 253 nm
SMILES
ClC1=C(N2C)C=C(C/C(C)=C/C=C/[C@@H](OC)[C@]3(O)NC(O[C@@]([C@@H](C)[C@@](O4)([H])[C@]4(C)[C@@H](O)CC2=O)([H])C3)=O)C=C1OC
InChi Code
InChI=1S/C28H37ClN2O8/c1-15-8-7-9-22(37-6)28(35)14-20(38-26(34)30-28)16(2)25-27(3,39-25)21(32)13-23(33)31(4)18-11-17(10-15)12-19(36-5)24(18)29/h7-9,11-12,16,20-22,25,32,35H,10,13-14H2,1-6H3,(H,30,34)/b9-7+,15-8+/t16-,20+,21+,22-,25+,27+,28+/m1/s1
InChi Key
QWPXBEHQFHACTK-RZKXNLMUSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $134

    Add

    25 mg

    $301

    Add

    50 mg

    $466

    Add

    100 mg

    $729

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Maytansinol is an ansa macrolide originally isolated from P. verrucose that has antimitotic and anticancer activities.1,2,3 It inhibits polymerization and induces depolymerization of bovine brain tubulin with EC50 values of 12 and 43 µM, respectively.2 Maytansinol inhibits sea urchin egg mitosis when used at a concentration of 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 µg/ml).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kupchan, S.M., Branfman, A.R., Sneden, A.T., et al. Novel maytansinoids. Naturally occurring and synthetic antileukemic esters of maytansinol. J. Am. Chem. Soc. 97(18), 5294-5295 (1975).

    2. Ikeyama, S., and Takeuchi, M. Antitubulin activities of ansamitocins and maytansinoids. Biochem. Pharmacol. 30(17), 2421-2425 (1981).

    3. Kupchan, S.M., Sneden, A.T., Branfman, A.R., et al. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids. J. Med. Chem. 21(1), 31-37 (1978).