A PRMT5 inhibitor
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JNJ-64619178

Item No. 29231

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2R,3S,5R)-3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol
CAS Number
2086772-26-9
Molecular Formula
C22H23BrN6O2
Formula Weight
483.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
214, 233 nm
SMILES
O[C@H]1[C@@H](O)[C@@](N2C=CC3=C(N)N=CN=C32)([H])C[C@@H]1CCC4=CC=C(C=C(Br)C(N)=N5)C5=C4
InChi Code
InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
InChi Key
DBSMLQTUDJVICQ-CJODITQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $117

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    1 mg

    $218

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    Cayman Chemical
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    Product Description

    JNJ-64619178 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 0.14 nM).1 It inhibits the growth of various cancer cells in vitro and reduces tumor growth in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tao, H., Yan, X., Zhu, K., et al. Discovery of novel PRMT5 inhibitors by virtual screening and biological evaluations. Chem. Pharm. Bull. (Tokyo) 67(4), 382-388 (2019).

    2. Wu, T., Millar, H., Gaffney, D., et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models. Cancer Res. 78(13_suppl.), 4859 (2018).