A thymidylate synthase inhibitor
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Nolatrexed (hydrochloride)

Item No. 29247

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone, dihydrochloride
CAS Number
152946-68-4
Synonyms
  • AG337
Molecular Formula
C14H12N4OS • 2HCl
Formula Weight
357.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
λmax
232, 273 nm
SMILES
NC1=NC(C2=C(SC3=CC=NC=C3)C(C)=CC=C2N1)=O.Cl.Cl
InChi Code
InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
InChi Key
PJKVJJYMWOCLIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).1 It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Webber, S., Bartlett, C.A., Boritzki, T.J., et al. AG337, a novel lipophilic thymidylate synthase inhibitor: In vitro and in vivo preclinical studies. Cancer Chemother. Pharmacol. 37(6), 509-517 (1996).