For immunochemical detection of CGRP
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CGRP Monoclonal Antibody (Clone 4901)

Item No. 29254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Calcitonin Gene-Related Peptide
Immunogen
Rat α-CGRP
Source
10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol
Clone Designation
4901
Formulation (Request formulation change)
100 µl of protein G-purified mouse monoclonal antibody
Host
Mouse
Isotype
IgG2a
Applications
ICC
Species Reactivity
(+) Rat α-CGRP(+) Rat β-CGRP(+) Human α-CGRP
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $510

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    Product Description

    Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide.1 It exists in two major forms that share greater than 90% sequence homology, α-CGRP that is produced by alternative RNA splicing of the calcitonin gene CALCI and β-CGRP that is encoded by CALCII in humans. CGRP is primarily expressed in A and Cδ fibers and exhibits perivascular localization but is also expressed in keratinocytes and endothelial progenitor cells.1,2 CGRP binds to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) and has roles in efferent function, nociception, and vasodilation. Levels of CGRP are increased in various pain states, including migraine. It also suppresses TNF-α, increases fibroblast motility and extracellular matrix synthesis, and induces Schwann cell proliferation to facilitate peripheral nerve regeneration following injury.3 Cayman’s CGRP Monoclonal Antibody (Clone 4901) can be used for ICC applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Russell, F.A., King, R., Smillie, S.-J., et al. Calcitonin gene-related peptide: Physiology and pathophysiology. Physiol. Rev. 94(4), 1099-1142 (2014).

    2. Iyengar, S., Ossipov, M.H., and Johnson, K.W. The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 158(4), 543-559 (2017).

    3. Chung, A.M. Calcitonin gene-related peptide (CGRP): Role in peripheral nerve regeneration. Rev. Neurosci. 29(4), 369-376 (2018).