For immunochemical detection of c-Fos
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c-Fos Monoclonal Antibody

Item No. 29262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • AP-1 Transcription Factor Subunit
  • FBJ Murine Osteosarcoma Viral Oncogene Homolog
  • Fos Proto-oncogene
  • Proto-oncogene c-Fos
Immunogen
Recombinant human full-length c-Fos
Formulation (Request formulation change)
100 µl of protein G-purified monoclonal antibody
Storage Buffer
PBS with 5 mM sodium azide and 50% glycerol
Host
Mouse
Applications
ICC, IHC, WB
Species Reactivity
(+) Bovine(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $555

    Add
    Cayman Chemical
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    Product Description

    c-Fos is a widely expressed nuclear protein and member of the Fos protein family that includes c-Fos, FosB, Fra-1, and Fra-2.1 It is a proto-oncogene that contains a leucine zipper motif to facilitate heterodimerization with Jun family proteins, such as c-Jun, to form the transcription factor complex activator protein-1 (AP-1) that has roles in cell proliferation, differentiation, and apoptosis. Expression of c-fos is induced in response to growth factors, tumor promoters, cytokines, and UV radiation.1,2 In neurons, c-fos expression is induced upon depolarization and is widely used as a marker of neuronal activation.3 c-fos is also overexpressed in a variety of tumor cells, and transgenic overexpression of c-fos in mice induces formation of chondrosarcomas.2,4 Cayman's c-Fos Monoclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes c-Fos at approximately 50 kDa from human, bovine, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kovács, K.J. c-Fos as a transcription factor: A stressful (re)view from a functional map. Neurochem. Int. 33(4), 287-297 (1998).

    2. Tkach, V., Tulchinsky, E., Lukanidin, E., et al. Role of the fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility. Oncogene 22(32), 5045-5054 (2003).

    3. Hoffman, G.E., Smith, M.S., and Verbalis, J.G. c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Front. Neuroendocrinol. 14(3), 173-213 (1993).

    4. Jacenko, O. c-fos and bone loss: A proto-oncogene regulates osteoclast lineage determination. BioEssays 17(4), 277-281 (1995).