FOX1 Monoclonal Antibody

FOX1, also known as ataxin-2-binding protein 1 (A2BP1) and RNA binding protein fox-1 homolog 1 (RBFOX1), is an RNA binding protein and alternative splicing regulator encoded by RBFOX1 in humans.^1,2,3 RBFOX1 is expressed in the brain, skeletal muscle, and heart and undergoes splicing to generate tissue-specific isoforms.⁴ Neuron-specific FOX1 regulates alternative splicing of genes involved in neuronal development, proliferation, and maintenance.¹ Mutations in RBFOX1, including exon deletion, frameshift, and copy number mutations, have been found in patients with rolandic epilepsy, autism, and schizophrenia.^2,5,6 Cayman's FOX1 Monoclonal Antibody can be used for immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes FOX1 isoforms at approximately 46 and 48 kDa from human, bovine, mouse, and rat samples.

WARNING This product is not for human or veterinary use.

1. Fogel, B.L., Wexler, E., Wahnich, A., et al. RBFOX1 regulates both splicing and transcriptional networds in human neuronal development. Hum. Mol. Genet. 21(19), 4171-4186 (2012).

2. Lal, D., Reinthaler, E.M., Altmüller, J., et al. RBFOX1 and RBFOX3 mutations in rolandic epilepsy. PLoS One 8(9), e73323 (2013).

3. Kuroyanagi, H. Fox-1 family of RNA-binding proteins. Cell. Mol. Life Sci. 66(24), 3895-3907 (2009).

4. Nakahata, S., and Kawamoto, S. Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res. 33(7), 2078-2089 (2005).

5. Martin, C.L., Duvall, J.A., Ilkin, Y., et al. Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B(7), 869-879 (2007).

6. Xu, B., Roos, J.L., Levy, S., et al. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat. Genet. 40(7), 880-885 (2008).