For immunochemical detection of the GABAA receptor β2 subunit
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GABAA Receptor β2 Subunit Polyclonal Antibody

Item No. 29274

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • GABAA Receptor Subunit β2
  • GABRB2
  • Gamma-aminobutyric Acid (GABA) A Receptor, β2
  • Gamma-aminobutyric Acid Receptor Subunit β2
Immunogen
Fusion protein from the cytoplasmic loop of the β2 subunit of the rat GABAA receptor
MW
~55 kDa
Formulation (Request formulation change)
100 µl of affinity-purified rabbit polyclonal antibody
Storage Buffer
10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol
Host
Rabbit
Applications
WB
Species Reactivity
(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $528

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    Product Description

    GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.1,2 They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.2,3 The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Phosphorylation of the β2 subunit by PKC inhibits binding of the β2 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.4 SNPs in GABRB2, which encodes the β2 subunit isoform, have been found in patients with schizophrenia.5 Cayman's GABAA Receptor β2 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor β2 subunit at approximately 55 kDa from mouse and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crestani, F., and Rudolph, U. Behavioral functions of GABAA receptor subtypes - the Zurich experience. Diversity and Functions of GABA receptors: A tribute to Hanns Möhler, part A 37-51 (2015).

    2. Hirose, S. Mutant GABAA receptor subunits in genetic (idiopathic) epilepsy. Genetics of epilepsy 55-85 (2014).

    3. Wongsamitkul, N., Maldifassi, M.C., Simeone, X., et al. α subunits in GABAA receptors are dispensable for GABA and diazepam action. Sci. Rep. 7(1), 15498 (2017).

    4. Vithlani, M., Moss, S.J., and Terunuma, M. The dynamic modulation of GABAA receptor trafficking and its role in the formation of inhibitory synapses. Physiol. Rev. 91(3), 1009-1022 (2011).

    5. Zhao, C., Xu, Z., Chen, J., et al. Two isoforms of GABAA receptor β2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia. Mol. Psychiatry 11(12), 1092-1105 (2006).