For immunochemical detection of mitochondria
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Mitochondria Monoclonal Antibody

Item No. 29283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Immunogen
Human mitochondrial homogenate
MW
~60 kDa
Formulation (Request formulation change)
100 µl of protein A-purified monoclonal antibody
Storage Buffer
PBS
Host
Mouse
Applications
ICC, IHC, WB
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $436

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    Product Description

    Mitochondria are organelles best known for their role in ATP production.1 They also have roles in cell cycle progression, apoptosis, carbohydrate and fatty acid catabolism, and the synthesis of steroids and other lipids. Mutations in mtDNA or nuclear genes encoding mitochondrial proteins are associated with a wide variety of human pathologies including Parkinson's disease, Charcot-Marie-Tooth (CMT) subtype 2A, and Leber hereditary optic neuropathy (LHON).2,3,4 Cayman's Mitochondria Monoclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes an undefined mitochondrial protein at approximately 60 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McBride, H.M., Neuspiel, M., and Wasiak, S. Mitochondria: More than just a powerhouse. Curr. Biol. 16(14), R551-R560 (2006).

    2. Chan, D.C. Mitochondria: Dynamic organelles in disease, aging, and development. Cell 125(7), 1241-1252 (2006).

    3. Raha, S., and Robinson, B.H. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci. 25(10), 502-508 (2000).

    4. Schapira, A.H.V. Mitochondrial disease. Lancet 368(9529), 70-82 (2006).