For immunochemical detection of Olig2
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Olig2 Polyclonal Antibody

Item No. 29288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Class B Basic Helix-Loop-Helix Protein 1
  • Class E Basic Helix-Loop-Helix Protein 19
  • Oligodendrocyte Lineage Transcription Factor 2
  • Oligodendrocyte-specific BHLH Transcription Factor 2
  • Oligo2
Immunogen
Recombinant mouse Olig2
MW
~32 kDa
Formulation (Request formulation change)
100 µl of protein A-purified polyclonal antibody
Storage Buffer
200 mM Tris, pH 8.0, with 100 mM glycine
Host
Rabbit
Applications
ICC, IHC, IP, WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $502

    Add
    Cayman Chemical
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    Product Description

    Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor that is essential to the formation of oligodendrocytes and motor neurons in the spinal cord and somatic motor neurons in the hindbrain.1 It represses differentiation and sustains the replication competent state of uncommitted progenitor cells to expand the progenitor cell pool during early development and promotes the cell fate decision to form oligodendrocyte progenitors and motor neurons in the spinal cord during late development. It also suppresses the formation of astrocytes in the spinal cord. Olig2 overexpression enhances oligodendrocyte regeneration and myelin repair in a mouse model of lysophosphatidylcholine-induced demyelination.2 Knockdown of Olig2 in neurospheres prevents glioma formation but not neurosphere engraftment in mice.3 Cayman's Olig2 Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes Olig1 at approximately 32 kDa from human, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meijer, D.H., Kane, M.F., Mehta, S., et al. Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat. Rev. Neurosci. 13(12), 819-831 (2012).

    2. Wegener, A., Deboux, C., Bachelin, C., et al. Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Brain 138(Pt. 1), 120-135 (2015).

    3. Ligon, K.L., Huillard, E., Mehta, S., et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 53(4), 503-517 (2007).