Olig2 (Phospho-Ser^10,13,14) Polyclonal Antibody

Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor that is essential to the formation of oligodendrocytes and motor neurons in the spinal cord and somatic motor neurons in the hindbrain.¹ It represses differentiation and sustains the replication-competent state of uncommitted progenitor cells to expand the progenitor cell pool during early development and promotes the cell fate decision to form oligodendrocyte progenitors and motor neurons in the spinal cord during late development. It also suppresses the formation of astrocytes in the spinal cord. Olig2 contains a triple serine motif at positions 10, 13, and 14 near its amino terminus that is subject to phosphorylation.² Phosphorylation of Olig2 at this motif (phospho-Ser^10,13,14) is developmentally regulated and decreases as Olig2⁺ progenitor cells mature into terminally differentiated oligodendrocytes. EB5 neurospheres expressing a triple phosphomimetic mutant of Olig2 induce more rapid tumor formation and decreased survival in mice compared with neurospheres expressing wild-type Olig2. Cayman's Olig2 (Phospho-Ser^10,13,14) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes Olig2 (phospho-Ser^10,13,14) at approximately 32 kDa from human, mouse, and rat samples.

WARNING This product is not for human or veterinary use.

1. Meijer, D.H., Kane, M.F., Mehta, S., et al. Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat. Rev. Neurosci. 13(12), 819-831 (2012).

2. Sun, Y., Meijer, D.H., Alberta, J.A., et al. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron 69(5), 906-917 (2011).