An inhibitor of norepinephrine and dopamine reuptake
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Nomifensine

Item No. 29330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
CAS Number
24526-64-5
Synonyms
  • (±)-Nomifensine
Molecular Formula
C16H18N2
Formula Weight
238.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): Partially soluble
λmax
242 nm
SMILES
NC1=C(CN(C)CC2C3=CC=CC=C3)C2=CC=C1
InChi Code
InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3
InChi Key
XXPANQJNYNUNES-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $49

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    50 mg

    $86

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    100 mg

    $152

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    Product Description

    Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake.1 It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM, respectively. It is selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes). Nomifensine is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and less than 57 µmol/kg, respectively. It decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats when administered at a chronic dose of 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyttel, J., and Larsen, J.J. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J. Neurochem. 44(5), 1615-1622 (1985).

    2. Tejani-Butt, S., Kluczynski, J., and Paré, W.P. Strain-dependent modification of behavior following antidepressant treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry 27(1), 7-14 (2003).