A mixture of monosialogangliosides
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Monosialoganglioside Mixture

Item No. 29359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation
A solution in chloroform:methanol:water (2:1:0.1)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 ml

    $283

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    Product Description

    Monosialogangliosides are membrane sphingolipids that contain one sialic acid residue.1 They have roles in cell proliferation, differentiation, and adhesion, as well as neuronal plasticity and repair.1,2,3 Monosialogangliosides accumulate in a variety of lysosomal storage disorders including Sandhoff, Tay-Sachs, and Niemann-Pick diseases.4,5 Monosialoganglioside Mixture contains the monosialogangliosides GM1 (Item No. 31548), GM2 (Item No. 31710), and GM3 (Item No. 31711) and is intended for use as a reference standard for the detection of these monosialogangliosides in various sample types by TLC or LC-MS. This mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. [Matreya, LLC. Catalog No. 1508]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolter, T. Ganglioside biochemistry. ISRN Biochem. 506160 (2012).

    2. Mukherjee, P., Faber, A.C., Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J. Lipid Res. 49(5), 929-938 (2008).

    3. Seyfried, T.N., and Mukherjee, P. Ganglioside GM3 is antiangiogenic in malignant brain cancer. J. Oncol. 961243 (2010).

    4. Baek, R.C., Martin, D.R., Cox, N.R., et al. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids 44(3), 197-205 (2009).

    5. Walkley, S.U. Secondary accumulation of gangliosides in lysosomal storage disorders. Semin. Cell Dev. Biol. 15(4), 433-444 (2004).