A mixture of gangliosides
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Ganglioside Mixture

Item No. 29362

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation
A solution in chloroform:methanol:water (2:1:0.1)
Solubility(Learn about Variance in Solubility)
Chloroform:Methanol:Water (2:1:0.1): soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 ml

    $283

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    Product Description

    Gangliosides are acidic membrane sphingolipids that contain sialic acid and oligosaccharide moieties.1 They have roles in cell proliferation, differentiation, adhesion, neuronal plasticity, intra- and intercellular signaling, and neurogenesis.1,2,3 They accumulate in a variety of lysosomal storage disorders including Sandhoff, Tay-Sachs, and Niemann-Pick diseases.4,5 Ganglioside Mixture contains the gangliosides asialo ganglioside GM1, ganglioside GM1, ganglioside GD1a, ganglioside GD1B, and ganglioside GT1b and is intended for use as a reference standard for the detection of these gangliosides in various sample types by TLC or LC-MS. This mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. [Matreya, LLC. Catalog No. 1511]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolter, T. Ganglioside biochemistry. ISRN Biochem. 506160 (2012).

    2. Mukherjee, P., Faber, A.C., Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J. Lipid Res. 49(5), 929-938 (2008).

    3. Wang, J., Cheng, A., Wakade, C., et al. Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain. J. Neurosci. 34(41), 13790-13800 (2014).

    4. Baek, R.C., Martin, D.R., Cox, N.R., et al. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids 44(3), 197-205 (2009).

    5. Walkley, S.U. Secondary accumulation of gangliosides in lysosomal storage disorders. Semin. Cell Dev. Biol. 15(4), 433-444 (2004).