A synthetic mineralocorticoid
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Fludrocortisone

Item No. 29391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11β)-9-fluoro-11,17,21-trihydroxy-pregn-4-ene-3,20-dione
CAS Number
127-31-1
Synonyms
  • Astonin-H
  • 9α-Fludrocortisone
  • Fluohydrocortisone
  • Fluorohydrocortisone
  • NSC 11318
Molecular Formula
C21H29FO5
Formula Weight
380.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleEthanol: slightly, sonicatedMethanol: slightly, sonicated
SMILES
F[C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O
InChi Code
InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
InChi Key
AAXVEMMRQDVLJB-BULBTXNYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $153

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    Product Description

    Fludrocortisone is a synthetic mineralocorticoid.1 Dietary administration of fludrocortisone (10 μg/kg per day) reduces tympanic membrane thickness and fluid area in a mouse model of S. pneumoniae-induced middle ear inflammation. Formulations containing fludrocortisone have been used in the treatment of Addison's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. MacArthur, C.J., DeGagne, J.M., Kempton, J.B., et al. Steroid control of acute middle ear inflammation in a mouse model. Arch. Otolaryngol. Head Neck Surg. 135(5), 453-457 (2009).