A synthetic progestin
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Chlormadinone Acetate

Item No. 29392

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-(acetyloxy)-6-chloro-pregna-4,6-diene-3,20-dione
CAS Number
302-22-7
Synonyms
  • NSC 92338
Molecular Formula
C23H29ClO4
Formula Weight
404.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 50 mg/ml
λmax
283 nm
SMILES
O=C1CC[C@@]2(C)C(C(Cl)=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4(C(C)=O)OC(C)=O)=C1
InChi Code
InChI=1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1
InChi Key
QMBJSIBWORFWQT-DFXBJWIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Chlormadinone acetate is a synthetic progestin.1 It binds to progesterone, androgen, and glucocorticoid receptors in vitro (Kis = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 µg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schneider, J., Kneip, C., and Jahnel, U. Comparative effects of chlormadinone acetate and its 3α- and 3β-hydroxy metabolites on progesterone, androgen and glucocorticoid receptors. Pharmacology 84(2), 74-81 (2009).