An inhibitor of α-synuclein-induced toxicity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ELN484228

Item No. 29398

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-fluorophenyl)-benzenesulfonamide
CAS Number
312-63-0
Synonyms
  • NSC 164389
Molecular Formula
C12H10FNO2S
Formula Weight
251.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
FC1=CC=C(NS(C2=CC=CC=C2)(=O)=O)C=C1
InChi Code
InChI=1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H
InChi Key
AZORQGXJAXEIGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $37

    Add

    10 mg

    $70

    Add

    50 mg

    $181

    Add

    100 mg

    $324

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    ELN484228 is an inhibitor of α-synuclein-induced toxicity.1 It prevents inhibition of phagocytosis induced by overexpression of α-synuclein in H4 neuroglioma cells when used at concentrations of 30, 100, and 300 µM. ELN484228 (10 µM) protects dopaminergic neurons from cell death and neurite retraction induced by A53T mutant α-synuclein in a rat midbrain culture model of Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toth, G., Gardai, S.J., Zago, W., et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson’s disease. PLoS One 9(2), 329 (2014).