An internal standard for the quantification of serotonin
Related Products
Unlabeled Version(s)
14332Serotonin (hydrochloride)
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Serotonin-d4 (hydrochloride)

Item No. 29415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-aminoethyl-1,1,2,2-d4)-1H-indol-5-ol, monohydrochloride
CAS Number
2469263-61-2
Synonyms
  • 5-HT-d4
  • 5-Hydroxytryptamine-d4
Molecular Formula
C10H8D4N2O • HCl
Formula Weight
216.7
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly solubleWater: Slightly soluble
SMILES
OC1=CC=C(NC=C2C([2H])([2H])C([2H])([2H])N)C2=C1.Cl
InChi Code
InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H/i3D2,4D2;
InChi Key
MDIGAZPGKJFIAH-URZLSVTISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $126

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    5 mg

    $471

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    10 mg

    $878

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    Product Description

    Serotonin-d4 is intended for use as an internal standard for the quantification of serotonin (Item No. 14332) by GC- or LC-MS. Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract.1,2,3,4 Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martinez, A., Knappskog, P.M., and Haavik, J. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosyntheis. Curr. Med. Chem. 8(9), 1077-1091 (2001).

    2. Liu, Q., Yang, Q., Sun, W., et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J. Pharmacol. Exp. Ther. 325(1), 47-55 (2008).

    3. Schmid, C.L., and Bohn, L.M. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a β-arrestin2/Src/Akt signaling complex in vivo. J. Neurosci. 30(40), 13513-13524 (2010).

    4. Berger, M., Gray, J.A., and Roth, B.L. The expanded biology of serotonin. Annu. Rev. Med. 60, 355-366 (2009).