An internal standard for the quantification of phentolamine
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Unlabeled Version(s)
16135Phentolamine (mesylate)
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Phentolamine-d4 (hydrochloride)

Item No. 29417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)methyl](4-methylphenyl)amino]-phenol, monohydrochloride
CAS Number
1346599-65-2
Molecular Formula
C17H15D4N3O • HCl
Formula Weight
321.8
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
CC(C=C1)=CC=C1N(C2=CC(O)=CC=C2)CC3=NC([2H])([2H])C([2H])([2H])N3.Cl
InChi Code
InChI=1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H/i9D2,10D2;
InChi Key
TUEJFGFQYKDAPM-PQDNHERISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $267

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    Product Description

    Phentolamine-d4 is intended for use as an internal standard for the quantification of phentolamine (Item No. 16135) by GC- or LC-MS. Phentolamine is a reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities.1,2,3,4 Formulations containing phentolamine have been used in the treatment of hypertensive emergencies, as well as chronic and emergent pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lomasney, J.W., Cotecchia, S., Lorenz, W., et al. Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor. The gene for which is located on human chromosome 5. The Journal of Biological Chemisty 266(10), 6365-6369 (1991).

    2. Millan, M.J., Newman-Tancredi, A., Audinot, V., et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2-adrenergic receptors (AR)s, serotonin (5-HT)1A, 5-HT1B, 5-HT1D and dopamine D2 and D3 receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse 35(2), 79-95 (2000).

    3. O'Rourke, M.F., Iversen, L.J., Lomasney, J.W., et al. Species orthologs of the Alpha-2A adrenergic receptor: The pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors. J. Pharmacol. Exp. Ther. 271(2), 735-740 (1994).

    4. Richelson, E., and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J. Pharmacol. Exp. Ther. 230(1), 94-102 (1984).