A sesquiterpene alcohol
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(−)-Drimenol

Item No. 29428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-1-naphthalenemethanol
CAS Number
468-68-8
Synonyms
  • NSC 169775
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CC1=CC[C@@]2([H])C(C)(C)CCC[C@]2(C)[C@H]1CO
InChi Code
InChI=1S/C15H26O/c1-11-6-7-13-14(2,3)8-5-9-15(13,4)12(11)10-16/h6,12-13,16H,5,7-10H2,1-4H3/t12-,13-,15+/m0/s1
InChi Key
HMWSKUKBAWWOJL-KCQAQPDRSA-N
Origin
Semi-synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    (–)-Drimenol is a sesquiterpene alcohol originally isolated from B. trilobata that has antimicrobial and anticancer activities.1,2,3 It is active against the bacteria S. aureus, B. cereus, A. baumanii, E. coli, and P. aeruginosa (MICs = 667, 667, 583, 1,333, and 667 µg/ml, respectively), as well as the fungi C. cucumerinum and S. tritici (IC50s = 6.6 and 80.1 µg/ml, respectively).1,2 (–)-Drimenol decreases the proliferation of A2058 and A375 melanoma cell lines with IC50 values of 33.5 and 31.25 µg/ml, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santos, T.G., Dognnini, J., Begnini, I.M., et al. Chemical characterization of essential oils from Drimys angustifolia miers (winteraceae) and antibacterial activity of their major compounds. J. Braz. Chem. Soc. 24(1), 164-170 (2013).

    2. Scher, J.M., Speakman, J.B., Zapp, J., et al. Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S.F. Gray. Phytochemistry 65(18), 2583-2588 (2004).

    3. Russo, A., Cardile, V., Graziano, A.C.E., et al. Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components. Chem. Biol. Interact. 305, 79-85 (2019).