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An Mcl-1 inhibitor
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Technical Information
Formal Name
7-[(4-ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol
CAS Number
315698-17-0
Molecular Formula
C23H24F3N3O
Formula Weight
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
250 nm
SMILES
CCN1CCN(C(C2=C(O)C(N=CC=C3)=C3C=C2)C4=CC=C(C(F)(F)F)C=C4)CC1
InChi Code
InChI=1S/C23H24F3N3O/c1-2-28-12-14-29(15-13-28)21(17-5-8-18(9-6-17)23(24,25)26)19-10-7-16-4-3-11-27-20(16)22(19)30/h3-11,21,30H,2,12-15H2,1H3
InChi Key
NGAPBLRRJSKIRT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data
Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.
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Product Description
ML-311 is an inhibitor of myeloid cell leukemia-1 (Mcl-1; IC50 = 0.31 µM in a fluorescence polarization assay).1 It is selective for Mcl-1 over Bcl-xL (IC50 = >40 µM). ML-311 decreases the proliferation of 13 cancer cell lines (EC50s = 0.3-25 µM).
WARNING This product is not for human or veterinary use.
References & Product Citations
Product Description References
1. Hydroxyquinoline-
Contact Info
Cayman Chemical1180 East Ellsworth RoadAnn Arbor, Michigan 48108 USAToll Free: (800) 364-9897(USA and Canada only)Fax: (734) 971-3640
