An oleanane-type saponin with anticancer activity
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Isomer(s)
40661Soyasaponin II
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Product Categories

Product Type

Biochemicals
Natural Products
Saponins

Research Area

Cancer

Pulsatilla Saponin D

Item No. 29455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α)-3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid
CAS Number
68027-15-6
Synonyms
  • Hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranoside
  • Hederacolchiside A
  • Pulchinenoside B3
Molecular Formula
C47H76O17
Formula Weight
913.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/ml
SMILES
CC1(C)CC[C@@]2(C(O)=O)[C@@](C3=CC[C@@]([C@](CC[C@H](O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)CO4)[C@]7(CO)C)(C)[C@@]7([H])CC8)([H])[C@]8(C)[C@]3(C)CC2)([H])C1
InChi Code
InChI=1S/C47H76O17/c1-22-30(50)33(53)35(55)38(60-22)64-37-32(52)26(62-39-36(56)34(54)31(51)25(19-48)61-39)20-59-40(37)63-29-11-12-43(4)27(44(29,5)21-49)10-13-46(7)28(43)9-8-23-24-18-42(2,3)14-16-47(24,41(57)58)17-15-45(23,46)6/h8,22,24-40,48-56H,9-21H2,1-7H3,(H,57,58)/t22-,24-,25+,26-,27+,28+,29-,30-,31+,32-,33+,34-,35+,36+,37+,38-,39-,40-,43-,44-,45+,46+,47-/m0/s1
InChi Key
SOLICHUQXFAOEP-YDIXZRNLSA-N
Origin
Plant/Pulsatilla chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $172

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    Product Description

    Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity.1 It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bang, S.-C., Lee, J.-H., Song, G.-Y., et al. Antitumor activity of Pulsatilla koreana saponins and their structure–activity relationship. Chem. Pharm. Bull. (Tokyo). 53(11), 1451-1454 (2005).