An inhibitor of dynamin
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Dyngo-4a

Item No. 29479

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2-naphthalenecarboxylic acid, 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
CAS Number
1256493-34-1
Molecular Formula
C18H14N2O5
Formula Weight
338.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
223, 290, 367 nm
SMILES
OC1=CC2=C(C=CC=C2)C=C1C(N/N=C/C3=CC(O)=C(O)C=C3O)=O
InChi Code
InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
InChi Key
UAXHPUSKEWEOAP-DJKKODMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    50 mg

    $461

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    100 mg

    $786

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    Product Description

    Dyngo-4a is an inhibitor of dynamin with IC50 values of 380 and 2,300 nM for native sheep brain dynamin 1 and recombinant rat dynamin 2, respectively.1 It inhibits dynamin 1 helix formation induced by L-phosphatidylserine (PS) liposomes (IC50 = 0.38 µM) more potently than dynamin 1 single-ring formation induced by Grb2 (IC50 = 39.2 µM) and does not inhibit the basal GTPase activity of dynamin.1,2 Dyngo-4a inhibits non-neuronal clathrin-mediated (IC50 = 5.7 µM in U2OS cells) and synaptic vesicle endocytosis (IC50 = 26.8 µM in rat brain synaptosomes).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCluskey, A., Daniel, J.A., Hadzic, G., et al. Building a better dynasore: The dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14(12), 1272-1289 (2013).

    2. Mohanakrishnan, A., Tran, T.V.M., Kumar, M., et al. A highly-sensitive high throughput assay for dynamin’s basal GTPase activity. PLoS One 12(9), e0185639 (2017).