A 5-HT1F receptor agonist
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LY334370 (hydrochloride)

Item No. 29481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-benzamide, monohydrochloride
CAS Number
199673-74-0
Molecular Formula
C21H22FN3O • HCl
Formula Weight
387.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleWater: soluble
λmax
228, 267 nm
SMILES
FC1=CC=C(C(NC2=CC(C(C3CCN(C)CC3)=CN4)=C4C=C2)=O)C=C1.Cl
InChi Code
InChI=1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H
InChi Key
DGPDGAPZTPSHBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $197

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    10 mg

    $262

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    Product Description

    LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Kd = 0.446 nM).1 It is selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM).2 It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wainscott, D.B., Krushinski, J.H., Jr., Audia, J.E., et al. [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn Schmiedebergs Arch. Pharmacol. 371(3), 169-177 (2005).

    2. Johnson, K.W., Schaus, J.M., Durkin, M.M., et al. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport 8(9-10), 2237-2240 (1997).