A 5-HT1B receptor agonist
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CP 94,253 (hydrochloride)

Item No. 29486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine, monohydrochloride
CAS Number
845861-39-4
Molecular Formula
C15H19N3O • HCl
Formula Weight
293.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
220, 258, 300 nm
SMILES
CCCOC1=CC=C2C(C(C3=CCNCC3)=CN2)=N1.Cl
InChi Code
InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
InChi Key
PIIOXKQIZCVXMD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $95

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    10 mg

    $168

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    25 mg

    $370

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    Product Description

    CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay).1 It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg.2 It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg.3 CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koe, B.K., Nielsen, J.A., Macor, J.E., et al. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev. Res. 26(3), 241-250 (1992).

    2. Fish, E.W., Faccidomo, S., and Miczek, K.A. Aggression heightened by alcohol or social instigation in mice: Reduction by the 5-HT1B receptor agonist CP-94,253. Psychopharmacology (Berl.) 146(4), 391-399 (1999).

    3. Tatarczyńska, E., Antkiewicz-Michaluk, L., Kłodzińska, A., et al. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: A possible mechanism of action. Eur. J. Pharmacol. 516(1), 46-50 (2005).

    4. Chojnacka-Wójcik, E., Kłodzińska, A., and Tatarczyńska, E. The anxiolytic-like effect of 5-HT1B receptor ligands in rats: A possible mechanism of action. J. Pharm. Pharmacol. 57(2), 253-257 (2005).