An alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Dihydroergocristine (mesylate)

Item No. 29492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,10α-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′α-(phenylmethyl)-ergotaman-3′,6′,18-trione, monomethanesulfonate
CAS Number
24730-10-7
Molecular Formula
C35H41N5O5 • CH3SO3H
Formula Weight
707.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
O=C([C@H]1CN(C)[C@@](CC2=CNC3=C2C4=CC=C3)([H])[C@]4([H])C1)N[C@]5(C(C)C)O[C@]([C@@](CCC6)([H])N6C([C@@H]7CC8=CC=CC=C8)=O)(O)N7C5=O.O=S(C)(O)=O
InChi Code
InChI=1S/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1
InChi Key
SPXACGZWWVIDGR-SPZWACKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $134

    Add
    Product Description

    Dihydroergocristine is an alkaloid with diverse biological activities.1,2,3,4 It inhibits contraction of isolated rat vas deferens induced by norepinephrine (pA2 = 7.88) but not calcium.1 Dihydroergocristine (0.1-100 µg/kg, i.v.) reduces blood pressure in a rat model of norepinephrine-induced hypertension and increases blood pressure in hypotensive rats.2 It reduces aqueous humor production and intraocular pressure in a rabbit model of α-chymotrypsin-induced ocular hypertension.3 Dihydroergocristine also reduces hypermotility induced by ethanol in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lucchelli, A., Zonta, F., Grana, E., et al. Dualism in the α-adrenoceptor blocking action of dihydroergocristine. Pharmacol. Res. Commun. 13(3), 231-240 (1981).

    2. Morpurgo, C., Faini, D., and Falcone, A. Effects of phentolamine, dihydroergocristine and isoxsuprine on the blood pressure and heart rate in normotensive, hypotensive and hypertensive rats. Naunyn Schmiedebergs Arch. Pharmacol. 290(4), 335-346 (1975).

    3. Melena, J., Santafe, J., and Segarra, J. The effect of topical dihydroergocristine on the intraocular pressure in alpha-chymotrypsin-induced ocular hypertensive rabbits. Methods Find. Exp. Clin. Pharmacol. 20(10), 861-867 (1998).

    4. Boada, J.N., Feria, M., Serrano, M., et al. Inhibitory effect of dihydroergocristine, phenoxybenzamine and propranolol on the hypermotility induced by low doses of ethyl alcohol in mice. Arch. Farmacol. Toxicol. 5(2), 117-122 (1979).