A synthetic retinoid and RARα agonist
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BMS 753

Item No. 29493

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
CAS Number
215307-86-1
Molecular Formula
C21H21NO4
Formula Weight
351.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
289 nm
SMILES
OC(C1=CC=C(NC(C2=CC(C(C)(C)C(C3(C)C)=O)=C3C=C2)=O)C=C1)=O
InChi Code
InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)
InChi Key
KFBPBWUZXBYJDG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    Cayman Chemical
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    Product Description

    BMS 753 is a synthetic retinoid and retinoic acid receptor α (RARα) agonist (Ki = 2 nM).1 It is selective for RARα over RARγ at 1 μM. BMS 753 (10 and 100 nM) induces morphological differentiation of P19 embryonal carcinoma cells, as well as F9 embryonal carcinoma cells when used at a concentration of at 100 nM in combination with the pan-retinoid X receptor (RXR) agonist BMS649.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Géhin, M., Vivat, V., Wurtz, J.M., et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem. Biol. 6(8), 519-529 (1999).

    2. Taneja, R., Roy, B., Plassat, J.L., et al. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc. Natl. Acad. Sci. USA 93(12), 6197-6202 (1996).