A potent histamine H3 receptor agonist
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Immethridine (hydrobromide)

Item No. 29502

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(1H-imidazol-5-ylmethyl)-pyridine, dihydrobromide
CAS Number
699020-93-4
Molecular Formula
C9H9N3 • 2HBr
Formula Weight
321.0
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C1(CC2=CN=CN2)=CC=NC=C1.Br.Br
InChi Code
InChI=1S/C9H9N3.2BrH/c1-3-10-4-2-8(1)5-9-6-11-7-12-9;;/h1-4,6-7H,5H2,(H,11,12);2*1H
InChi Key
CYNKWHIKNDIVDR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $178

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    10 mg

    $236

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    Product Description

    Immethridine is a potent histamine H3 receptor agonist (Ki = 0.85 nM).1 It is selective for histamine H3 over histamine H4 receptors (Ki = 245 nM). Immethridine inhibits cAMP-stimulated β-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM) and induces a concentration-dependent decrease of the electrically induced twitch contraction in isolated guinea pig ileum. In vivo, immethridine (30 mg/kg, s.c.) inhibits hydrochloric acid-induced formation of gastric lesions in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kitbunnadaj, R., Zuiderveld, O.P., Christophe, B., et al. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J. Med. Chem. 47(10), 2414-2417 (2004).

    2. Adami, M., Pozzoli, C., Leurs, R., et al. Histamine H3 receptors are involved in the protective effect of ghrelin against HCl-induced gastric damage in rats. Pharmacology 86(5-6), 259-266 (2010).