A histamine H2 receptor agonist
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Amthamine (hydrobromide)

Item No. 29503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4-methyl-5-thiazoleethanamine, dihydrobromide
CAS Number
142457-00-9
Molecular Formula
C6H11N3S • 2HBr
Formula Weight
319.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
λmax
264 nm
SMILES
NC1=NC(C)=C(CCN)S1.Br.Br
InChi Code
InChI=1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H
InChi Key
XFXNNOPUDSFVJE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $132

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    25 mg

    $262

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    Product Description

    Amthamine is a histamine H2 receptor agonist (pD2 = 6.21 in isolated guinea pig atria).1 It is selective for H2 over H3 receptors (pD2 = 4.7 in isolated guinea pig ileum). Amthamine increases heart rate in spontaneously beating isolated guinea pig atria (pD2 = 6.72) and decreases contractions induced by cholecystokinin (CCK) octapeptide in a dose-dependent manner in isolated guinea pig gallbladder strips.2,3 It increases sheep red blood cell-induced production of IgG and IgM antibodies in rabbit serum when administered at a dose of 10 µg/kg twice per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eriks, J.C., van der Groot, H., Sterk, G.J., et al. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. J. Med. Chem. 35(17), 3239-3246 (1992).

    2. Poli, E., Pozzoli, C., Coruzzi, G., et al. In vitro cardiac pharmacology of the new histamine H2-receptor agonist amthamine: Comparisons with histamine and dimaprit. Agents Actions 40(1-2), 44-49 (1993).

    3. Coruzzi, G., Pozzoli, C., Poli, E., et al. Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder. Fundam. Clin. Pharmacol. 13(1), 84-90 (1999).

    4. Tripathi, T., Shahid, M., Khan, H.M., et al. Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol. Rep. 62(5), 917-925 (2010).