A sulfate conjugate of p-cresol
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p-Cresol sulfate (potassium salt)

Item No. 29504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
sulfuric acid, mono(4-methylphenyl) ester, monopotassium salt
CAS Number
91978-69-7
Synonyms
  • 4-Cresyl sulfate
  • para-Cresol sulfate
Molecular Formula
C7H7O4S • K
Formula Weight
226.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC1=CC=C(OS([O-])(=O)=O)C=C1.[K+]
InChi Code
InChI=1S/C7H8O4S.K/c1-6-2-4-7(5-3-6)11-12(8,9)10;/h2-5H,1H3,(H,8,9,10);/q;+1/p-1
InChi Key
HTSFIPMTBJHYFQ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $39

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    250 mg

    $77

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    500 mg

    $116

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    1 g

    $174

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    Product Description

    p-Cresol sulfate is a sulfate conjugate of the uremic toxin p-cresol, which is formed by bacterial fermentation of proteins in the large intestine.1,2 p-Cresol sulfate increases migration and proliferation of isolated rat aortic vascular smooth muscle cells (VSMCs) when used at a concentration of 500 µM.3 It also increases the area of aortic atherosclerotic plaques in nephrectomized ApoE-/- mice fed a high-fat diet when administered at a dose of 100 mg/kg per day via the drinking water. Serum levels of total and free p-cresol sulfate are increased in patients with advanced stage chronic kidney disease and positively associated with vascular calcification.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, E.A., and Macfarlane, G.T. Enumeration of human colonic bacteria producing phenolic and indolic compounds: Effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J. Appl. Bacteriol. 81(3), 288-302 (1996).

    2. Meijers, B.K.I., and Evenepoel, P. The gut-kidney acis: Indoxyl sulfate, p-cresyl sulfate and CKD progression. Nephrol. Dial. Transplant. 26(3), 759-761 (2011).

    3. Han, H., Chen, Y., Zhu, Z., et al. p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells. Front. Med. 10(3), 320-329 (2016).

    4. Liabeuf, S., Barreto, D.V., Barreto, F.C., et al. Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease. Nephrol. Dial. Transplant. 25(4), 1183-1191 (2010).