A dopamine D4 receptor agonist
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ABT-724 (hydrochloride)

Item No. 29506

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride
CAS Number
587870-77-7
Molecular Formula
C17H19N5 • 3HCl
Formula Weight
402.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
λmax
245, 270, 276, 317 nm
SMILES
C12=CC=CC=C1NC(CN3CCN(C4=NC=CC=C4)CC3)=N2.Cl.Cl.Cl
InChi Code
InChI=1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H
InChi Key
AZFUVPBLKQGSRI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $57

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    10 mg

    $96

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    Product Description

    ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5.1 It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg.2 ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cowart, M., Latshaw, S.P., Bhatia, P., et al. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J. Med. Chem. 47(15), 3853-3864 (2004).

    2. Sanna, F., Contini, A., Melis, M.R., et al. Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male rats. Pharmacol. Biochem. Behav. 137, 110-118 (2015).

    3. Yin, P., Cao, A.-H., Yu, L., et al. ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Neurosci. Lett. 580, 142-146 (2014).