An amine-reactive fluorescent probe
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BODIPY FL succinimide ester

Item No. 29508

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-[1-[3-[5-[(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN]-1-oxopropoxy]-2,5-pyrrolidinedionato]difluoro-boron
CAS Number
146616-66-2
Synonyms
  • BODIPY FL NHS ester
  • BODIPY FL SE
  • EverFluor FL, SE
Molecular Formula
C18H18BF2N3O4
Formula Weight
389.2
Purity
≥95%
Emission
511 nm
Excitation
502 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CC1=[N+]2C(C(C)=C1)=CC3=CC=C(CCC(ON4C(CCC4=O)=O)=O)N3[B-]2(F)F
InChi Code
InChI=1S/C18H18BF2N3O4/c1-11-9-12(2)22-15(11)10-14-4-3-13(23(14)19(22,20)21)5-8-18(27)28-24-16(25)6-7-17(24)26/h3-4,9-10H,5-8H2,1-2H3
InChi Key
SDVMGNSTOAJONW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $297

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    Product Description

    BODIPY FL succinimide ester (BODIPY FL SE) is an amine-reactive fluorescent probe.1 It displays excitation/emission maxima of 502/511 nm, respectively. BODIPY FL SE has been used in the synthesis of protease substrates that are non-fluorescent until unquenched following proteolytic cleavage.2 It has also been used in the synthesis of a fluorescent verapamil derivative and of fluorescent inhibitors of cholesterol absorption.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D'Amore, C., Orso, G., Forgiarini, A., et al. Synthesis and biological characterization of a new norbormide derived BODIPY FL-conjugated fluorescent probe for cell imaging. Front. Pharmacol. 9, 1055 (2018).

    2. Jones, L.J., Upson, R.H., Haugland, R.P., et al. Quenched BODIPY dye-labeled casein substrates for the assay of protease activity by direct fluorescence measurement. Anal. Biochem. 251(2), 144-152 (1997).

    3. Kubo, Y., Nakazawa, A., Akanuma, S.I., et al. Blood-to-retina transport of fluorescence-labeled verapamil at the blood-retinal barrier. Pharm. Res. 35(5), 93 (2018).

    4. Burnett, D.A., Caplen, M.A., Browne, M.E., et al. Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors. Bioorg. Med. Chem. Lett. 12(3), 315-318 (2002).