An MT2 receptor agonist
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8-M-PDOT

Item No. 29521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-propanamide
CAS Number
134865-70-6
Synonyms
  • AH 002
Molecular Formula
C14H19NO2
Formula Weight
233.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
COC1=CC=CC2=C1CC(NC(CC)=O)CC2
InChi Code
InChI=1S/C14H19NO2/c1-3-14(16)15-11-8-7-10-5-4-6-13(17-2)12(10)9-11/h4-6,11H,3,7-9H2,1-2H3,(H,15,16)
InChi Key
RVIGBTUDFAGRTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $152

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    25 mg

    $357

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    50 mg

    $667

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    Product Description

    8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM).1 It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson's disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Browning, C., Beresford, I., Fraser, N., et al. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br. J. Pharmacol. 129(5), 877-886 (2000).

    2. Noseda, A.C., Targa, A.D., Rodrigues, L.S., et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 9(1), 47-54 (2016).