An internal standard for the quantification of 3β-hydroxy-7-oxo-5-cholestenoic acid
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3β-hydroxy-7-oxo-5-Cholestenoic Acid-d3

Item No. 29539

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-hydroxy-7-oxo-cholest-5-en-26-oic-27,27,27-d3 acid
CAS Number
2342573-92-4
Synonyms
  • 3β-hydroxy-7-oxo-5-CA-d3
  • 3β-hydroxy-7-oxocholest-5-enoic Acid-d3
Molecular Formula
C27H39D3O4
Formula Weight
433.6
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.25 mg/ml
SMILES
O=C1C=C2C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@]1([H])[C@@](CC[C@]4([H])[C@@H](CCCC(C([2H])([2H])[2H])C(O)=O)C)([H])[C@]4(C)CC3
InChi Code
InChI=1S/C27H42O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h15-17,19-22,24,28H,5-14H2,1-4H3,(H,30,31)/t16-,17?,19+,20-,21+,22+,24+,26+,27-/m1/s1/i2D3
InChi Key
QOEPZHFZXUROGV-XCGRDMFNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $448

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    Product Description

    3β-hydroxy-7-oxo-5-Cholestenoic Acid-d3 is intended for use as an internal standard for the quantification of 3β-hydroxy-7-oxo-5-cholestenoic acid by GC- or LC-MS. 3β-hydroxy-7-oxo-5-Cholestenoic acid is a metabolite of the oxysterol 7-keto cholesterol (Item No. 16339).1 It is formed from 7-keto cholesterol by the cytochrome P450 (CYP) isoform CYP27A1. Plasma levels of 3β-hydroxy-7-oxo-5-cholestenoic acid are increased in a rat model of liver injury induced by carbon tetrachloride.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heo, G.-Y., Bederman, I., Mast, N., et al. Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. J. Lipid Res. 52(6), 1117-1127 (2011).

    2. Xu, S.-Y., Zhang, Y., Han, T., et al. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry-based plasma metabolomics study of hepatoprotective effect of cuscutae semen on CCl4 -induced liver injury model of rats. Biomed. Chromatogr. 36(12), e5489 (2022).