A fluorescent substrate for NADH:ubiquinone oxidoreductases
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Coumarin-Quinone Conjugate

Item No. 29554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(diethylamino)-2-oxo-2H-1-benzopyran-3-carboxylic acid, (2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methyl ester
CAS Number
2741190-31-6
Molecular Formula
C24H25NO6
Formula Weight
423.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
λmax
212, 259, 421 nm
SMILES
O=C1OC2=CC(N(CC)CC)=CC=C2C=C1C(OCC3=C(C)C(C(C)=C(C)C3=O)=O)=O
InChi Code
InChI=1S/C24H25NO6/c1-6-25(7-2)17-9-8-16-10-18(24(29)31-20(16)11-17)23(28)30-12-19-15(5)21(26)13(3)14(4)22(19)27/h8-11H,6-7,12H2,1-5H3
InChi Key
QJCBHBXUOMJXSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $926

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    Product Description

    Coumarin-quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases.1 It is comprised of a coumarin fluorophore conjugated to a ubiquinone analog that can be reduced by NADH:ubiquinone oxidoreductases. It has been used to measure the kinetic parameters of apoptosis-inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Doll, S., Freitas, F.P., Shah, R., et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575(7784), 693-698 (2019).

    Product Citations

    Hendricks, J.M., Doubravsky, C., Wehri, E., et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem. Biol. 30(9), P1090-P1103 (2022).