A post-ganglionic sympathetic blocker
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Debrisoquin (hemisulfate)

Item No. 29568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-2(1H)-isoquinolinecarboximidamide, hemisulfate
CAS Number
581-88-4
Synonyms
  • Isocaramidine sulfate
  • Ro 5-3307/1
Molecular Formula
C10H13N3 • 1/2H2SO4
Formula Weight
224.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
NC(N1CCC2=CC=CC=C2C1)=N.O=S(O)(O)=O
InChi Code
InChI=1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)
InChi Key
CAYGYVYWRIHZCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $40

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    50 mg

    $171

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    100 mg

    $283

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    250 mg

    $655

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    Product Description

    Debrisoquin is a post-ganglionic sympathetic blocker.1 It increases accumulation of the monoamine oxidase (MAO) substrate l-m-octopamine in isolated rabbit heart when used at a concentration of 1 mM.2 Debrisoquin reduces norepinephrine levels in the left and right atrium and ventricles, as well as the mesenteric and femoral arteries in anesthetized dogs when administered at a dose of 5 mg/kg per day for seven days.3 Debrisoquin decreases mean aortic pressure, heart rate, and total peripheral vascular resistance in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heffernan, A.G.A., and Carty, A.T. Clinical observations on the use of debrisoquine sulphate (declinax) in the treatment of hypertension. I. J. Med. Sc. 3(1), 37-43 (1970).

    2. Giachetti, A., and Shore, P.A. Monoamine oxidase inhibition in the adrenergic neuron by bretylium, debrisoquin, and other adrenergic neuronal blocking agents. Biochem. Pharmacol. 16, 237-238 (1966).

    3. Cavero, I., Gerold, M., Saner, A., et al. The cardiovascular effects of the antihypertensive drug debrisoquin: A contribution to the pharmacology of chronic treatment. I. one-week administration to dogs. J. Pharmacol. Exp. Ther. 206(1), 123-131 (1978).