An internal standard for the quantification of tiamulin
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Unlabeled Version(s)
21216Tiamulin (fumarate)
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Tiamulin-d10 (hydrochloride)

Item No. 29580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aR,4S,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((2-(bis(ethyl-d5)amino)ethyl)thio)acetate, monohydrochloride
CAS Number
2750534-93-9
Molecular Formula
C28H37D10NO4S • HCl
Formula Weight
540.3
Purity
≥99% deuterated forms (d1-d10)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
aqueous base: slightly soluble
SMILES
O=C1CC[C@@]2(CC[C@H]3C)[C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CSCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=O)[C@@]3(C)[C@@]21[H].Cl
InChi Code
InChI=1S/C28H47NO4S.ClH/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1H/t19-,20+,22-,24+,25+,26-,27+,28+;/m1./s1/i2D3,3D3,9D2,10D2;
InChi Key
WRHXJTYYMRJQPZ-MNCFBAAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $436

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    Product Description

    Tiamulin-d10 is intended for use as an internal standard for the quantification of tiamulin (Item No. 21216) by GC- or LC-MS. Tiamulin is a pleuromutilin antibiotic.1 It is active against M. gallisepticum, M. synoviae, M. iowae, M. hyopneumoniae, M. hyosynoviae, M. hyorhinis, M. bovis, and M. agalactiae (MICs = 0.0025-0.25 µg/ml). Tiamulin is also active against various Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA).2 Tiamulin binds to the peptidyl transferase in the 50S ribosomal subunit to inhibit protein synthesis. Formulations containing tiamulin have been used in the treatment of veterinary enteric diseases and enzootic pneumonia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hannan, P.C.T., Windsor, G.D., de Jong, A., et al. Comparative susceptibilities of various animal-pathogenic mycoplasmas to fluoroquinolones. Antimicrob. Agents Chemother. 41(9), 2037-2040 (1997).

    2. Wilson, D.N. The A-Z of bacterial translation inhibitors. Crit. Rev. Biochem. Mol. Biol. 44(6), 393-433 (2009).