Eupatorin

Eupatorin is a flavonoid that has been found in L. camara and has diverse biological activities.^1,2,3,4 It inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI₅₀s = 15, 58, and 44 µM, respectively).¹ Eupatorin is active against T. cruzi epimastigotes and trypomastigotes (IC₅₀s = 0.2 and 61.8 µg/ml, respectively) without inducing cytotoxicity in Vero cells (IC₅₀ = >500 µg/ml).² It induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD₂ = 6.66).³ Eupatorin (10 and 100 µM) reduces nuclear translocation of NF-κB and STAT1α in J774 murine macrophages and reduces paw edema in a mouse model of carrageenan-induced paw inflammation when administered at a dose of 50 mg/kg.⁴

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1. Nagao, T., Abe, F., Kinjo, J., et al. Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biol. Pharm. Bull. 25(7), 875-879 (2002).

2. Beer, M.F., Frank, F.M., Germán Elso, O., et al. Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifolia. Pharm. Biol. 54(10), 2188-2195 (2016).

3. Yam, M.F., Tan, C.S., Ahmad, M., et al. Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring. Eur. J. Pharmacol. 789, 27-36 (2016).

4. Laavola, M., Nieminen, R., Yam, M.F., et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med. 78(8), 779-786 (2012).