An endogenous inhibitory amino acid and antioxidant
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Hypotaurine

Item No. 29614

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-ethanesulfinic acid
CAS Number
300-84-5
Molecular Formula
C2H7NO2S
Formula Weight
109.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NCCS(O)=O
InChi Code
InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
InChi Key
VVIUBCNYACGLLV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $55

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    250 mg

    $129

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    Product Description

    Hypotaurine is an endogenous inhibitory amino acid.1 It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 μM).2 It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM).3 It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays.4 Hypotaurine (1 mM) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kragler, A., Höfner, G., and Wanner, K.T. Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4. Eur. J. Pharmacol. 519(1-2), 43-47 (2005).

    2. Borden, L.A., Smith, K.E., Gustafson, E.L., et al. Cloning and expression of a betaine/GABA transporter from human brain. J. Neurochem. 64(3), 977-984 (1995).

    3. Ramanathan, V.K., Brett, C.M., and Giacomini, K.M. Na+-dependent γ-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochim. Biophys. Acta 1330(1), 94-102 (1997).

    4. Aruoma, O.I., Halliwell, B., Hoey, B.M., et al. The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem. J. 256(1), 251-255 (1988).

    5. Nishimura, T., Duereh, M., Sugita, Y., et al. Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts. Placenta 36(6), 693-698 (2015).