An anthelmintic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Rafoxanide

Item No. 29616

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-benzamide
CAS Number
22662-39-1
Synonyms
  • NSC 355278
Molecular Formula
C19H11Cl2I2NO3
Formula Weight
626.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml
λmax
222, 338, 386 nm
SMILES
IC1=CC(I)=C(O)C(C(NC2=CC(Cl)=C(OC3=CC=C(Cl)C=C3)C=C2)=O)=C1
InChi Code
InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChi Key
NEMNPWINWMHUMR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $49

    Add

    500 mg

    $93

    Add

    1 g

    $171

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Rafoxanide is an anthelmintic.1,2,3 In vivo, rafoxanide (50 mg/kg) completely eradicates E. caproni infection in mice.1 It is active against H. contortus in sheep when administered at a dose of 10 mg/kg and eliminates mature F. hepatica flukes in cattle when administered at a dose of 7.5 mg/kg.2,3 It is also cytotoxic to A375 and A431 skin cancer cells in vitro (IC50s = 10.9 and 1.31 µM, respectively) and reduces tumor growth in an A375 mouse xenograft model when administered at a dose of 40 mg/kg.3 Formulations containing rafoxanide have been used in the treatment of parasitic infections in sheep and cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. K., M., Decere, M., and Fried, B. Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice. J. Helminthol. 70(1), 95-96 (1996).

    2. Egerton, J.R., Yakstis, J.J., and Campbell, W.C. Efficacy of rafoxanide (3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy) salicylanilide) against Haemonchus contortus in sheep. Res. Vet. Sci. 11(4), 382-388 (1970).

    3. Knapp, S.E., and Presidente, P.J.A. Efficacy of rafoxanide against natural fasciola hepatica infections in cattle. Am. J. Vet. Res. 32(8), 1289-1291 (1971).