Peiminine

Peiminine is an alkaloid that has been found in Fritillaria and has diverse biological activities.^1,2,3 It increases protein levels of the autophagy marker LC3B-II and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner.¹ Peiminine (3 mg/kg every other day) reduces tumor growth in an HCT116 mouse xenograft model. It has antitussive effects in a mouse cough model induced by ammonia liquor when administered at a dose of 3 mg/kg.² Peiminine (5 mg/kg) reduces dermal and epidermal thickness, inhibits dermal infiltration of eosinophils and mast cells, and decreases serum levels of IgE, IL-4, and TNF-α in a mouse model of atopic dermatitis induced by dinitrochlorobenzene (DNCB).³

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1. Lyu, Q., Tou, F., Su, H., et al. The natural product peiminine represses colorectal carcinoma tumor growth by inducing autophagic cell death. Biochem. Biophys. Res. Commun. 462(1), 38-45 (2015).

2. Wang, D., Zhu, J., Wang, S., et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia 82(8), 1290-1294 (2011).

3. Lim, J.-M., Lee, B., Min, J.-H., et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro. Int. Immunopharmacol. 56, 135-142 (2018).