A COMT inhibitor
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Ro 41-0960

Item No. 29621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanone
CAS Number
125628-97-9
Molecular Formula
C13H8FNO5
Formula Weight
277.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
219, 258, 278 nm
SMILES
OC1=C(O)C=C(C(C2=CC=CC=C2F)=O)C=C1[N+]([O-])=O
InChi Code
InChI=1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
InChi Key
RQPAUNZYTYHKHA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $80

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    25 mg

    $173

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    Product Description

    Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.1 It prevents dopaminergic neuron loss induced by L-DOPA (Item No. 13248) in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 µM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.2 It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine (Item No. 21992) and 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Storch, A., Blessing, H., Bareiss, M., et al. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol. Pharmacol. 57(3), 589-594 (2000).

    2. Rivas, E., de Ceballos, M.L., Nieto, O., et al. In vivo effects of new inhibitors of catechol-O-methyl transferase. Br. J. Pharmacol. 126(7), 1667-1673 (1999).

    3. Hassan, M.H., Fouad, H., Bahashwan, S., et al. Towards non-surgical therapy for uterine fibroids: Catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model. Hum. Reprod. 26(11), 3008-3018 (2011).