A prodrug form of niflumic acid
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Active Metabolite(s)
70650Niflumic Acid
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Talniflumate

Item No. 29623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
CAS Number
66898-62-2
Synonyms
  • BA 7602-06
Molecular Formula
C21H13F3N2O4
Formula Weight
414.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 2 mg/mlEthanol: Partially soluble
SMILES
O=C1C2=CC=CC=C2C(OC(C3=CC=CN=C3NC4=CC(C(F)(F)F)=CC=C4)=O)O1
InChi Code
InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)
InChi Key
ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $42

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    10 mg

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    25 mg

    $183

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    50 mg

    $343

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    Product Description

    Talniflumate is a prodrug form of the COX-2 inhibitor niflumic acid (Item No. 70650).1 It decreases the rate of chloride/bicarbonate exchange by 55% in isolated mouse intestinal villous epithelial cells when used at a concentration of 100 µM.2 Dietary administration of talniflumate (88 mg/kg per day) increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jang, D.-J., Park, J.-S., Ko, H.-R., et al. Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatography. Biomed. Chromatogr. 19(1), 32-35 (2005).

    2. Walker, N.M., Simpson, J.E., Levitt, R.C., et al. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. J. Pharmacol. Exp. Ther. 317(1), 275-283 (2006).