An alkaloid with diverse biological activities
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Isomer(s)
43570Liensinine
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Daurisoline

Item No. 29628

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R)-1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
CAS Number
70553-76-3
Synonyms
  • (–)-Daurisoline
  • (R,R)-Daurisoline
Molecular Formula
C37H42N2O6
Formula Weight
610.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:10): 0.09mg/mLEthanol: 2mg/mL
SMILES
COC(C(OC)=C1)=CC2=C1CCN(C)[C@@H]2CC3=CC=C(OC4=C(O)C=CC(C[C@H]5N(C)CCC6=C5C=C(O)C(OC)=C6)=C4)C=C3
InChi Code
InChI=1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
InChi Key
BURJAQFYNVMZDV-FIRIVFDPSA-N
Origin
Plant/Rhizoma menispermi
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $402

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    50 mg

    $702

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    Product Description

    Daurisoline is an alkaloid that has been found in M. dauricum and has diverse biological activities.1,2,3 It enhances cytotoxicity induced by camptothecin (Item No. 11694) in HeLa cells when used at a concentration of 10 µM.1 Daurisoline inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively). It inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM).2 Daurisoline prolongs action potential duration (APD) and reduces early afterdepolarizations (EADs) in papillary muscle preparations isolated from hypertrophied rabbit hearts when used at a concentration of 15 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, M.-Y., Wang, S.-F., Cai, C.-Z., et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget 8(44), 77673-77684 (2017).

    2. Hu, S.-M., Xu, S.-X., Yao, X.-S., et al. Dauricoside, a new glycosidal alkaloid having an inhibitory activity against blood-platelet aggregation. Chem. Pharm. Bull. (Tokyo) 41(10), 1866-1868 (1993).

    3. Liu, Q.-N., Zhang, L., Gong, P.-L., et al. Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current. Am. J. Chin. Med. 38(1), 37-49 (2010).