A coumarin antibiotic
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Dihydronovobiocin

Item No. 29649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[7-[[3O-(aminocarbonyl)-6-deoxy-5C-methyl-4O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1benzopyran-3-yl]-4-hydroxy-3-(3-methylbutyl)-benzamide
CAS Number
29826-16-2
Molecular Formula
C31H38N2O11
Formula Weight
614.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O[C@H]1[C@H](OC2=CC=C(C(O)=C(NC(C3=CC(CCC(C)C)=C(O)C=C3)=O)C(O4)=O)C4=C2C)OC(C)(C)[C@H](OC)[C@H]1OC(N)=O
InChi Code
InChI=1S/C31H38N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h9-14,23,25-26,29,34-36H,7-8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1
InChi Key
JJYCENBZIMIWTM-KGSXXDOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dihydronovobiocin is a coumarin antibiotic and derivative of novobiocin (Item No. 18457).1 It is active against the bacteria S. aureus, S. haemolyticus, D. pneumoniae, S. typhosa, K. pneumoniae, and P. multocida (MICs = 0.6, 2, 0.6, 10, 10, and 3 µg/ml, respectively).2 Dihydronovobiocin inhibits DNA gyrase subunit B with an IC50 value of 64.5 nM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berger, J., and Batcho, A.D. Coumarin - glycoside antibiotics. J. Chromatogr. Lib. 15, 101-158 (1978).

    2. Hoeksema, H. Dihydronovobiocin and derivatives thereof. 3,175,944, 1-9 (1965).

    3. Gevi, M., and Domenici, E. A scintillation proximity assay amenable for screening and characterization of DNA gyrase B subunit inhibitors. Anal. Biochem. 300(1), 34-39 (2002).