A fluorescent DNA-intercalating agent
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Quinacrine mustard (hydrochloride)

Item No. 29653

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-1,4-pentanediamine, dihydrochloride
CAS Number
4213-45-0
Synonyms
  • NSC 3424
Molecular Formula
C23H28Cl3N3O • 2HCl
Formula Weight
541.8
Purity
≥85%
Emission
480 nm
Excitation
425 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleWater: soluble
λmax
222, 280, 424 nm
SMILES
COC1=CC2=C(C=C1)N=C3C(C=CC(Cl)=C3)=C2NC(CCCN(CCCl)CCCl)C.Cl.Cl
InChi Code
InChI=1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H
InChi Key
JETDZFFCRPFPDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $41

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    10 mg

    $72

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    25 mg

    $167

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    50 mg

    $312

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    Product Description

    Quinacrine mustard is a fluorescent DNA-intercalating agent.1 It selectively binds to adenine-thymine (AT) base pairs over guanine-cytosine (GC) base pairs.2,3 Quinacrine mustard has been used to label metaphase chromosomes for karyotyping by autoradiography.1 It displays excitation/emission maxima of 425/480 nm, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caspersson, T., Farber, S., Foley, G.E., et al. Chemical differentiation along metaphase chromosomes. Exp. Cell Res. 49(1), 219-222 (1968).

    2. Ellison, J.R., and Barr, H.J. Quinacrine fluorescence of specific chromosome regions. Late replication and high A:T content in Samoaia leonensis. Chromosoma 36(4), 375-390 (1972).

    3. Weisblum, B., and De Haseth, P.L. Quinacrine, a chromosome stain specific for deoxyadenylate-deoxythymidylate-rich regions in DNA. Proc. Natl. Acad. Sci. USA 69(3), 629-632 (1972).

    4. Chen, R.F. Fluorescence of quinacrine mustard conjugated to proteins. Arch. Biochem. Biophys. 172(1), 39-50 (1976).