A diterpene alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Hypaconitine

Item No. 29656

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,6α,14α,15α,16β)-1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-8,13,14,15-tetrol, 8-acetate 14-benzoate
CAS Number
6900-87-4
Molecular Formula
C33H45NO10
Formula Weight
615.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 10mg/mLEthanol: 5mg/mL
λmax
231 nm
SMILES
CO[C@@H]1C2(C3N4C)[C@@]([C@@H](OC)C3[C@]([C@@H](O)[C@H](OC)[C@]5(O)[C@@H]6OC(C7=CC=CC=C7)=O)(OC(C)=O)[C@]6([H])[C@]2(C5)[H])([H])[C@](COC)(C4)CC1
InChi Code
InChI=1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21-,22?,23+,24-,25?,26+,27-,28+,30+,31-,32?,33-/m1/s1
InChi Key
FIDOCHXHMJHKRW-WNDRHIBVSA-N
Origin
Plant/Aconitum carmichaelii Debx
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $90

    Add

    10 mg

    $158

    Add

    25 mg

    $328

    Add

    50 mg

    $609

    Add
    Product Description

    Hypaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.1,2 It inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM).1 Hypaconitine (0.025 mg/kg) prevents carrageenan-induced paw edema and reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg).2,3 Hypaconitine is toxic to mice (LD50 = 1.9 mg/kg, s.c.).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muroi, M., Kimura, I., and Kimura, M. Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice. Neuropharmacology 29(6), 567-572 (1990).

    2. Nesterova, Y.V., Povetieva, T.N., Suslov, N.I., et al. Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense. Bull. Exp. Biol. Med. 156(5), 665-668 (2014).

    3. Murayama, M., Mori, T., Bando, H., et al. Studies on the constituents of Aconitum species. IX. The pharmacological properties of pyro-type aconitine alkaloids, components of processed aconite powder 'kako-bushi-matsu': Analgesic, antiinflammatory and acute toxic activities. J. Ethnopharmacol. 35(2), 159-164 (1991).