A positive allosteric modulator of FFAR2/GPR43
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(±)-4-CMTB

Item No. 29680

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide
CAS Number
300851-67-6
Molecular Formula
C14H15ClN2OS
Formula Weight
294.8
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:2): 0.3mg/mLEthanol: 3mg/mL
λmax
223, 269 nm
SMILES
ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1
InChi Code
InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)
InChi Key
AZYDQCGCBQYFSE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Product Description

    (±)-4-CMTB is a positive allosteric modulator of free fatty acid receptor 2 (FFAR2/GPR43) with an EC50 value of 0.42 µM for [35S]GTPγS binding to 293 T-REx cell membranes expressing the human receptor.1 It selectively induces ERK1/2 phosphorylation in 293 T-REx cells expressing human FFAR2, but not FFAR1 or FFAR3.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, N.J., Ward, R.J., Stoddart, L.A., et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol. Pharmacol. 80(1), 163-173 (2011).