A fluorogenic HDAC substrate
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Boc-Lys(Ac)-AMC

Item No. 29682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-5-(acetylamino)-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]pentyl]-carbamic acid, 1,1-dimethylethyl ester
CAS Number
233691-67-3
Molecular Formula
C23H31N3O6
Formula Weight
445.5
Purity
≥98%
Emission
440-460 nm
Excitation
340-360 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 3 mg/ml
λmax
211, 229, 328 nm
SMILES
O=C1C=C(C)C2=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C2O1
InChi Code
InChI=1S/C23H31N3O6/c1-14-12-20(28)31-19-13-16(9-10-17(14)19)25-21(29)18(8-6-7-11-24-15(2)27)26-22(30)32-23(3,4)5/h9-10,12-13,18H,6-8,11H2,1-5H3,(H,24,27)(H,25,29)(H,26,30)/t18-/m0/s1
InChi Key
SUTRDULVNIPNLW-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $109

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    25 mg

    $244

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    50 mg

    $425

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    Product Description

    Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs).1 Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wegener, D., Wirsching, F., Riester, D., et al. A fluorogenic histone deacetylase assay well suited for high-throughput activity screening. Chem. Biol. 10(1), 61-68 (2003).