An FPP synthase inhibitor
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Neridronic Acid

Item No. 29692

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P,P′-(6-amino-1-hydroxyhexylidene)bis-phosphonic acid
CAS Number
79778-41-9
Synonyms
  • Neridronate
Molecular Formula
C6H17NO7P2
Formula Weight
277.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
SMILES
NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O
InChi Code
InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
InChi Key
PUUSSSIBPPTKTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $105

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    50 mg

    $363

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    100 mg

    $543

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    Cayman Chemical
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    Product Description

    Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay).1 It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 µM.2 Neridronic acid (30 µM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs).3 It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dunford, J.E., Kwaasi, A.A., Rogers, M.J., et al. Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: Time-dependent inhibition of human farnesyl pyrophosphate synthase. J. Med. Chem. 51(7), 2187-2195 (2008).

    2. Nicolin, V., Bareggi, R., Baldini, G., et al. Effects of neridronic acid on osteoclasts derived by physiological dual-cell cultures. Acta Histochem. 109(5), 397-402 (2007).

    3. Ribatti, D., Nico, B., Mangieri, D., et al. Neridronate inhibits angiogenesis in vitro and in vivo. Clin. Rheumatol. 26(7), 1094-1098 (2007).

    4. Schenk, R., Eggli, P., Fleisch, H., et al. Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat. Calcif. Tissue Int. 38(6), 342-349 (1986).