An mtMGST1 inhibitor
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Hexylglutathione

Item No. 29695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-γ-glutamyl-S-hexyl-L-cysteinyl-glycine
CAS Number
24425-56-7
Synonyms
  • S-Hexylglutathione
  • NSC 131114
Molecular Formula
C16H29N3O6S
Formula Weight
391.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleDMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
SMILES
CCCCCCSC[C@@H](C(NCC(O)=O)=O)NC(CC[C@H](N)C(O)=O)=O
InChi Code
InChI=1S/C16H29N3O6S/c1-2-3-4-5-8-26-10-12(15(23)18-9-14(21)22)19-13(20)7-6-11(17)16(24)25/h11-12H,2-10,17H2,1H3,(H,18,23)(H,19,20)(H,21,22)(H,24,25)/t11-,12-/m0/s1
InChi Key
HXJDWCWJDCOHDG-RYUDHWBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Hexylglutathione is a mitochondrial membrane-bound microsomal glutathione S-transferase 1 (mtMGST1) inhibitor (IC50 = 0.48 mM).1 It also inhibits the dopachrome tautomerase activity of macrophage migration inhibitory factor (MIF; IC50 = 3.3 mM).2 It has been used as an affinity chromatography ligand to purify glutathione S-transferase (GST) from sheep liver homogenate.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ulziikhishig, E., Lee, K.K., Hossain, Q.S., et al. Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A. Life Sci. 86(19-20), 726-732 (2010).

    2. Swope, M.D., Sun, H.W., Klockow, B., et al. Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione. The Journal of Biological Chemisty 273(24), 14877-14884 (1998).

    3. Reddy, C.C., Burgess, Z.Z., Gong, Z.Z., et al. Purification and characterization of the individual glutathione S-transferases from sheep liver. Arch. Biochem. Biophys. 224(1), 87-101 (1983).